updated 01.08.2025
2025
Efthimiou O, Hoogland J, Debray TPA, Aponte Ribero V, Knol W, Koek HL, Schwenkglenks M, Henrard S, Egger M, Rodondi N, White IR. Measuring the Performance of Survival Models to Personalize Treatment Choices. Stat Med. 2025 Mar 30;44(7):e70050. doi: 10.1002/sim.70050. PMID: 40207416; PMCID: PMC11983264.
Stuber MJ, Brockhus LA, Spinewine A, O’Mahony D, Jennings E, Dalleur O, Knol W, Koek HL, Baggio S, Rodondi N, Aubert CE. Central Nervous System-Active Medications and Risk of Hospital Readmission in Older Multimorbid Adults. J Am Geriatr Soc. 2025 Aug 29. doi: 10.1111/jgs.70049. Epub ahead of print. PMID: 40879205.
Gastens V, Chiolero A, Feller M, Bauer DC, Rodondi N, Del Giovane C. Development and internal validation of a new life expectancy estimator for multimorbid older adults. Diagn Progn Res. 2025 Mar 4;9(1):5. doi: 10.1186/s41512-025-00185-9. PMID: 40033449; PMCID: PMC11877760.
2024
Falke C, Karapinar F, Bouvy M, Emmelot M, Belitser S, Boland B, O’Mahony D, Murphy KD, Haller M, Salari P, Schwenkglenks M, Rodondi N, Egberts T, Knol W. The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy. Eur Geriatr Med. 2024 Dec;15(6):1713-1723. doi: 10.1007/s41999-024-01036-4. Epub 2024 Aug 20. Erratum in: Eur Geriatr Med. 2024 Dec;15(6):1725-1730. doi: 10.1007/s41999-024-01072-0. PMID: 39162972; PMCID: PMC11631809.
Aponte Ribero V, Efthimiou O, Abolhassani N, Alwan H, Bauer DC, Henrard S, Christiaens A, O’Mahony D, Knol W, Peters MJL, Chiolero A, Aujesky D, Waeber G, Rodondi N, Del Giovane C, Gencer B. Diabetes and the risk of cardiovascular events and all-cause mortality among older adults: an individual participant data analysis of five prospective studies. Eur J Clin Invest. 2025 Feb;55(2):e14340. doi: 10.1111/eci.14340. Epub 2024 Oct 28. PMID: 39465996; PMCID: PMC11744924.
Bienfait A, Lagreula J, Blum MR, Rodondi N, Sallevelt BTGM, Knol W, O’Mahony D, Spinewine A, Boland B, Dalleur O. Antipsychotic prescribing and drug-related readmissions in multimorbid older inpatients: a post-hoc analysis of the OPERAM population. Int J Clin Pharm. 2024 Jun;46(3):656-664. doi: 10.1007/s11096-024-01700-6. Epub 2024 Feb 17. PMID: 38367103.
2023
Ribero VA, Alwan H, Efthimiou O, Abolhassani N, Bauer DC, Henrard S, Christiaens A, Waeber G, Rodondi N, Gencer B, Del Giovane C. Cardiovascular disease and type 2 diabetes in older adults: a combined protocol for an individual participant data analysis for risk prediction and a network meta-analysis of novel anti-diabetic drugs. medRxiv [Preprint]. 2023 Mar 13:2023.03.13.23287105. doi: 10.1101/2023.03.13.23287105. PMID: 36993427; PMCID: PMC10055459.
Sibille FX, de Saint-Hubert M, Henrard S, Aubert CE, Goto NA, Jennings E, Dalleur O, Rodondi N, Knol W, O’Mahony D, Schwenkglenks M, Spinewine A. Benzodiazepine Receptor Agonists Use and Cessation Among Multimorbid Older Adults with Polypharmacy: Secondary Analysis from the OPERAM Trial. Drugs Aging. 2023 Jun;40(6):551-561. doi: 10.1007/s40266-023-01029-1. Epub 2023 May 23. PMID: 37221407; PMCID: PMC10232614.
Baretella O, Alwan H, Feller M, Aubert CE, Del Giovane C, Papazoglou D, Christiaens A, Meinders AJ, Byrne S, Kearney PM, O’Mahony D, Knol W, Boland B, Gencer B, Aujesky D, Rodondi N. Overtreatment and associated risk factors among multimorbid older patients with diabetes. J Am Geriatr Soc. 2023 Sep;71(9):2893-2901. doi: 10.1111/jgs.18465. Epub 2023 Jun 7. PMID: 37286338.
Salari P, Henrard S, O’Mahony C, Welsing P, Bhadhuri A, Jungo KT, Beck T, O’Mahony D, Byrne S, Spinewine A, Knol W, Rodondi N, Schwenkglenks M. Healthcare Costs and Health-Related Quality of Life in Older Multimorbid Patients After Hospitalization. Health Serv Insights. 2023 Feb 5;16:11786329231153278. doi: 10.1177/11786329231153278. PMID: 36760460; PMCID: PMC9903041.
Christiaens A, Baretella O, Del Giovane C, Rodondi N, Knol W, Peters M, Jennings E, O’Mahony D, Spinewine A, Boland B, Henrard S. Association between diabetes overtreatment in older multimorbid patients and clinical outcomes: an ancillary European multicentre study. Age Ageing. 2023 Jan 8;52(1):afac320. doi: 10.1093/ageing/afac320. PMID: 36626323; PMCID: PMC9831262.
Aubert CE, Blum MR, Gastens V, Dalleur O, Vaillant F, Jennings E, Aujesky D, Thompson W, Kool T, Kramers C, Knol W, O’Mahony D, Rodondi N. Prescribing, deprescribing and potential adverse effects of proton pump inhibitors in older patients with multimorbidity: an observational study. CMAJ Open. 2023 Feb 28;11(1):E170-E178. doi: 10.9778/cmajo.20210240. PMID: 36854455; PMCID: PMC9981164.
2022
Sallevelt BTGM, Egberts TCG, Huibers CJA, Ietswaart J, Drenth-van Maanen AC, Jennings E, O’Mahony C, Jungo KT, Feller M, Rodondi N, Sibille FX, Spinewine A, van Puijenbroek EP, Wilting I, Knol W. Detectability of Medication Errors With a STOPP/START-Based Medication Review in Older People Prior to a Potentially Preventable Drug-Related Hospital Admission. Drug Saf. 2022 Dec;45(12):1501-1516. doi: 10.1007/s40264-022-01237-5. Epub 2022 Nov 1. PMID: 36319944; PMCID: PMC9700573.
Gastens V, Chiolero A, Anker D, Schneider C, Feller M, Bauer DC, Rodondi N, Del Giovane C. Development and validation of a new prognostic index for mortality risk in multimorbid adults. PLoS One. 2022 Aug 5;17(8):e0271923. doi: 10.1371/journal.pone.0271923. PMID: 35930547; PMCID: PMC9355209.
Schneider C, Aubert CE, Del Giovane C, Donzé JD, Gastens V, Bauer DC, Blum MR, Dalleur O, Henrard S, Knol W, O’Mahony D, Curtin D, Lee SJ, Aujesky D, Rodondi N, Feller M. Comparison of 6 Mortality Risk Scores for Prediction of 1-Year Mortality Risk in Older Adults With Multimorbidity. JAMA Netw Open. 2022 Jul 1;5(7):e2223911. doi: 10.1001/jamanetworkopen.2022.23911. PMID: 35895059; PMCID: PMC9331084.
Aubert CE, Rodondi N, Terman SW, Feller M, Schneider C, Oberle J, Dalleur O, Knol W, O’Mahony D, Aujesky D, Donzé J. HOSPITAL Score and LACE Index to Predict Mortality in Multimorbid Older Patients. Drugs Aging. 2022 Mar;39(3):223-234. doi: 10.1007/s40266-022-00927-0. Epub 2022 Mar 9. PMID: 35260994; PMCID: PMC8934762.
Aubert CE, Rodondi N, Netzer S, Dalleur O, Spinewine A, Maanen CD, Knol W, O’Mahony D, Aujesky D, Donzé J. Predictors of 1-year drug-related admissions in older multimorbid hospitalized adults. J Am Geriatr Soc. 2022 May;70(5):1510-1516. doi: 10.1111/jgs.17667. Epub 2022 Jan 22. PMID: 35064571; PMCID: PMC9305949.
Huibers CJA, Sallevelt BTGM, Heij JMJO, O’Mahony D, Rodondi N, Dalleur O, van Marum RJ, Egberts ACG, Wilting I, Knol W. Hospital physicians’ and older patients’ agreement with individualised STOPP/START-based medication optimisation recommendations in a clinical trial setting. Eur Geriatr Med. 2022 Jun;13(3):541-552. doi: 10.1007/s41999-022-00633-5. Epub 2022 Mar 15. PMID: 35291025; PMCID: PMC9151543.
Salari P, O’Mahony C, Henrard S, Welsing P, Bhadhuri A, Schur N, Roumet M, Beglinger S, Beck T, Jungo KT, Byrne S, Hossmann S, Knol W, O’Mahony D, Spinewine A, Rodondi N, Schwenkglenks M. Cost-effectiveness of a structured medication review approach for multimorbid older adults: Within-trial analysis of the OPERAM study. PLoS One. 2022 Apr 11;17(4):e0265507. doi: 10.1371/journal.pone.0265507. PMID: 35404990; PMCID: PMC9000111.
Zerah L, Henrard S, Thevelin S, Feller M, Meyer-Massetti C, Knol W, Wilting I, O’Mahony D, Crowley E, Dalleur O, Spinewine A. Performance of a trigger tool for detecting drug-related hospital admissions in older people: analysis from the OPERAM trial. Age Ageing. 2022 Jan 6;51(1):afab196. doi: 10.1093/ageing/afab196. Erratum in: Age Ageing. 2022 Mar 1;51(3):afac043. doi: 10.1093/ageing/afac043. PMID: 34794171.
Thevelin S, Pétein C, Metry B, Adam L, van Herksen A, Murphy K, Knol W, O’Mahony D, Rodondi N, Spinewine A, Dalleur O. Experience of hospital-initiated medication changes in older people with multimorbidity: a multicentre mixed-methods study embedded in the OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM) trial. BMJ Qual Saf. 2022 Dec;31(12):888-898. doi: 10.1136/bmjqs-2021-014372. Epub 2022 Mar 29. PMID: 35351779; PMCID: PMC9685735.
2021
Blum MR, Sallevelt BTGM, Spinewine A, O’Mahony D, Moutzouri E, Feller M, Baumgartner C, Roumet M, Jungo KT, Schwab N, Bretagne L, Beglinger S, Aubert CE, Wilting I, Thevelin S, Murphy K, Huibers CJA, Drenth-van Maanen AC, Boland B, Crowley E, Eichenberger A, Meulendijk M, Jennings E, Adam L, Roos MJ, Gleeson L, Shen Z, Marien S, Meinders AJ, Baretella O, Netzer S, de Montmollin M, Fournier A, Mouzon A, O’Mahony C, Aujesky D, Mavridis D, Byrne S, Jansen PAF, Schwenkglenks M, Spruit M, Dalleur O, Knol W, Trelle S, Rodondi N. Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial. BMJ. 2021 Jul 13;374:n1585. doi: 10.1136/bmj.n1585. Erratum in: BMJ. 2022 Dec 1;379:o2859. doi: 10.1136/bmj.o2859. PMID: 34257088; PMCID: PMC8276068.
Papazoglou DD, Baretella O, Feller M, et al. Cross-sectional study on the prevalence of influenza and pneumococcal vaccination and its association with health conditions and risk factors among hospitalized multimorbid older patients. PLOS ONE. 2021.
Zerah L, Henrard S, Wilting I, et al. Prevalence of drug-drug interactions in older people before and after hospital admission: analysis from the OPERAM trial. BMC Geriatrics. 2021.
Shen Z, Spruit M. Automatic Extraction of Adverse Drug Reactions from Summary of Product Characteristics. Applied Sciences. 2021.
Dautzenberg L, Beglinger S, Tsokani S, et al. Interventions for preventing falls and fall‐related fractures in community‐dwelling older adults: A systematic review and network meta‐analysis. Journal of the American Geriatrics Society. 2021.
Dautzenberg L, Bretagne L, Koek HL, et al. Medication review interventions to reduce hospital readmissions in older people. Journal of the American Geriatrics Society. 2021.
Anrys P, Petit AE, Thevelin S, et al. An International Consensus List of Potentially Clinically Significant Drug-Drug Interactions in Older People. Journal of the American Medical Directors Association. 2021.
Petropoulou M, Efthimiou O, Rücker G, et al. A review of methods for addressing components of interventions in meta-analysis. PLOS ONE. 2021.
Sallevelt BTGM, Huibers CJA, Heij JMJO, Egberts TCG, van Puijenbroek EP, Shen Z, Spruit MR, Jungo KT, Rodondi N, Dalleur O, Spinewine A, Jennings E, O’Mahony D, Wilting I, Knol W. Frequency and Acceptance of Clinical Decision Support System-Generated STOPP/START Signals for Hospitalised Older Patients with Polypharmacy and Multimorbidity. Drugs Aging. 2022 Jan;39(1):59-73. doi: 10.1007/s40266-021-00904-z. Epub 2021 Dec 8. PMID: 34877629; PMCID: PMC8752546.
Gastens V, Del Giovane C, Anker D, Feller M, Syrogiannouli L, Schwab N, Bauer DC, Rodondi N, Chiolero A. Development and validation of a life expectancy estimator for multimorbid older adults: a cohort study protocol. BMJ Open. 2021 Aug 25;11(8):e048168. doi: 10.1136/bmjopen-2020-048168. PMID: 34433596; PMCID: PMC8388271.
2020
Bhadhuri A, Kind P, Salari P, et al. Measurement properties of EQ-5D-3L and EQ-5D-5L in recording self-reported health status in older patients with substantial multimorbidity and polypharmacy. Health and Quality of Life Outcomes. 2020.
Crowley EK, Sallevelt BTGM, Huibers CJA, et al. Intervention protocol: OPtimising thERapy to prevent avoidable hospital Admission in the Multi-morbid elderly (OPERAM): a structured medication review with support of a computerised decision support system. BMC Health Serv Res. 2020.
2019
Shen Z, van Krimpen H, Spruit M. A Lightweight API-Based Approach for Building Flexible Clinical NLP Systems. J Healthc Eng. 2019.
Shen Z, Spruit M. A Systematic Review of Open Source Clinical Software on GitHub for Improving Software Reuse in Smart Healthcare. Applied Sciences. 2019; 9(1):150. https://doi.org/10.3390/app9010150
2018
Hansen CR, O’Mahony D, Kearney PM, et al. Identification of behaviour change techniques in deprescribing interventions: a systematic review and meta-analysis. Br J Clin Pharmacol. 2018.
O Riordan D, Aubert CE, Walsh KA, et al. Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study. BMJ Open. 2018.
Beuscart JB, Knol W, Cullinan S, et al. International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy. BMC Med. 2018.
2017
Beuscart JB, Dalleur O, Boland B, et al. Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol. Clin Interv Aging. 2017.
Beuscart JB, Pont LG, Thevelin S, et al. A systematic review of the outcomes reported in trials of medication review in older patients: the need for a core outcome set. Br J Clin Pharmacol. 2017.
Chaimani A, Caldwell DM, Li T, Higgins JPT, Salanti G. Additional considerations are required when preparing a protocol for a systematic review with multiple interventions. J Clin Epidemiol. 2017.
Petropoulou M, Mavridis D. A comparison of 20 heterogeneity variance estimators in statistical synthesis of results from studies: a simulation study. Stat Med. 2017.
